Interferometer approach improves bio-sensor sensitivity
March 03, 2014 // Christoph Hammerschmidt
A research team of the Toyohashi University of Technology has developed a label-free biosensor that overcomes the weakness of conventional MEMS-based biosensors for medical and pharmaceutical applications. Utilizing a Fabry-Perot interferometer, the researchers succeeded in raising the sensor's sensitivity by a factor of 100.
Label-free biosensors are used in many laboratory applications including rapid diagnosis, tailor-made medication and drug discovery. Label-free MEMS-based sensors detect molecules by measuring the deflection of cantilevers caused by biomolecular adsorption. This approach however suffers from poor sensitivity because of low conversion efficiency of linear transducing from the mechanical deflection to the readout signal.
The research team around Kazuhiro Takahashi from the Toyohashi University has developed a biosensor based on MEMS Fabry-Perot interferometer integrated with a photodiode which utilises the non-linear optical transmittance change in the Fabry-Perot interference to enhance the sensitivity. The theoretical minimum detectable surface stress of the proposed sensor was predicted to be -1 µN/m, which is two orders of magnitude greater than that of the conventional MEMS sensor.
The sensor was fabricated using a 4-inch p-type silicon wafer. The photodiode was integrated into the silicon substrate using ion implantation of phosphorus. Sacrificial polysilicon was isotropically etched to form a freestanding membrane. Amino-methyl-functionalized parylene was coated on the membrane for immobilization of the biomolecules via electrostatic coupling.
The MEMS Fabry–Perot interferometric sensor allows the use of a universal biochemical sensing platform in a label-free manner, the research team claims.All news
Spread Spectrum Frequency Modulation Reduces Automotive LED Driver EMI
January 30, 2015
The large number of electronics in an automobile must have reasonably low electromagnetic interference (EMI) in order to ...
Privately-owned car not on the red list, study says
Private equity buys Canadian MEMS foundry
Tronics launches IPO
Samsung shows Europe its technology shopping list
Fuel cells in trucks: silent power instead of idling motors
January 28, 2015
Researchers of the Jülich research centre are developing a new type of fuel cells. Running on diesel fuel, it will be robust ...
Can Kevlar prevent lithium-ion battery fire risks?
VTT sets up Cyber War Room
320x320-mm OLED panel claims world's highest lumen-price ratio
- Sensing Elements for Current Measurements
- Investigating Die attach Failure in IGBTs using Power Cycling Tests
- Power Semiconductor Failure Diagnosis using Thermal Characterization and Power Cycling
- Top 5 Trends in Product Development and Test Engineering
InterviewCEO interview: Bosch's IoT startup is all about the system
Thorsten Mueller, CEO of Bosch Connected Devices and Solutions GmbH (Reutlingen, Germany), has been guiding the latest startup subsidiary of Robert Bosch GmbH since 2013 when he started the initiative ...
Filter WizardCheck out the Filter Wizard Series of articles by Filter Guru Kendall Castor-Perry which provide invaluable practical Analog Design guidelines.
Linear video channel
READER OFFERRead more
To ensure you have a good start in 2015, Freescale is giving away five of its QorIQ TWR-LS1021A Tower system modules, worth USD269 each, for EETimes Europe's readers to win.
The module is the most feature-rich and high-performance Tower system offered by Freescale, enabling compatibility and interoperability with the growing list of Tower expansion modules, offering an easily accessible...MORE INFO AND LAST MONTH' WINNERS...
December 15, 2011 | Texas instruments | 222901974
Unique Ser/Des technology supports encrypted video and audio content with full duplex bi-directional control channel over a single wire interface.