Interferometer approach improves bio-sensor sensitivity
March 03, 2014 // Christoph Hammerschmidt
A research team of the Toyohashi University of Technology has developed a label-free biosensor that overcomes the weakness of conventional MEMS-based biosensors for medical and pharmaceutical applications. Utilizing a Fabry-Perot interferometer, the researchers succeeded in raising the sensor's sensitivity by a factor of 100.
Label-free biosensors are used in many laboratory applications including rapid diagnosis, tailor-made medication and drug discovery. Label-free MEMS-based sensors detect molecules by measuring the deflection of cantilevers caused by biomolecular adsorption. This approach however suffers from poor sensitivity because of low conversion efficiency of linear transducing from the mechanical deflection to the readout signal.
The research team around Kazuhiro Takahashi from the Toyohashi University has developed a biosensor based on MEMS Fabry-Perot interferometer integrated with a photodiode which utilises the non-linear optical transmittance change in the Fabry-Perot interference to enhance the sensitivity. The theoretical minimum detectable surface stress of the proposed sensor was predicted to be -1 µN/m, which is two orders of magnitude greater than that of the conventional MEMS sensor.
The sensor was fabricated using a 4-inch p-type silicon wafer. The photodiode was integrated into the silicon substrate using ion implantation of phosphorus. Sacrificial polysilicon was isotropically etched to form a freestanding membrane. Amino-methyl-functionalized parylene was coated on the membrane for immobilization of the biomolecules via electrostatic coupling.
The MEMS Fabry–Perot interferometric sensor allows the use of a universal biochemical sensing platform in a label-free manner, the research team claims.All news
Startup uses phase-change material for displays, glazing
December 01, 2015
Bodle Technologies Ltd. (Oxford, England) is a startup company formed in August 2015 to make use of the optical properties ...
Interchangeable cells make traction batteries cheaper
The great IoT threat: how to avoid common security pitfalls during application development
Driven by IEEE Standards, Ethernet Hits the Road in 2016
Toshiba considers listing or partial sale of chip business
Transparent LED displays built on monolayer semiconductors
November 30, 2015
A research team led by engineers at UC Berkeley and Lawrence Berkeley National Laboratory has found a simple way to fix the ...
Startup wants to be the ARM of neuromorphic cores
A tech correction is coming
Delayed roadmap set for debut at TSensors Summit
- Digital Power System Management - Take Control of Your Power Supplies
- Battery Size Matters
- Software-Defined Radio Handbook - 11th edition
- Multichemistry Buck Battery Charger Controller
InterviewCEO interview: InvenSense's Abdi on expanding MEMS horizons
InvenSense Inc. is a MEMS company that has epitomized a fabless approach to a sector that is still highly reliant on a thorough grasp of the manufacturing and packaging processes. We interviewed CEO Behrooz ...
Filter WizardCheck out the Filter Wizard Series of articles by Filter Guru Kendall Castor-Perry which provide invaluable practical Analog Design guidelines.
Linear video channel
READER OFFERRead more
This month, Microsemi is giving away two SmartFusion2 dual-axis motor control starter kits, worth 9 each, for EETimes Europe's readers to win.
The kit will let you try out Microsemi's deterministic motor control solution, compliant with industry coding standards for developing safe and reliable software for embedded applications.
December 15, 2011 | Texas instruments | 222901974
Unique Ser/Des technology supports encrypted video and audio content with full duplex bi-directional control channel over a single wire interface.